Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

T. Connolly, Daniel; M. Heuvelman, Deborah; Nelson, R; V. Olander, Jitka; L. Eppley, Barry; J Delfino, J; R. Siegel, Ned; M. Leimgruber, Richard; Feder, Joseph

doi:10.1172/jci114322

Public

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

Published in Journal of Clinical Investigation • Nov 1, 1989

Authors:

Daniel T. Connolly

Deborah M. Heuvelman

R Nelson

Abstract

Vascular permeability factor (VPF) is an Mr 40-kD protein that has been purified from the conditioned medium of guinea pig line 10 tumor cells grown in vitro, and increases fluid permeability from blood vessels when injected intradermally. Addition of VPF to cultures of vascular endothelial cells in...

Subject

Angiogenesis

Endothelial stem cell

Vascular endothelial growth factor

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