<i>Helicobacter pylori</i> Caga Protein Can Be Tyrosine Phosphorylated in Gastric Epithelial Cells

Asahi, Momoyo; Azuma, Takeshi; Ito, Shigeji; Ito, Yoshiyuki; Suto, Hiroyuki; Nagai, Yukifumi; Tsubokawa, Misao; Tohyama, Yumi; Maeda, Shin; Omata, Masao; Suzuki, Toshihiko; Sasakawa, Chihiro

doi:10.1084/jem.191.4.593

Public

Helicobacter pylori Caga Protein Can Be Tyrosine Phosphorylated in Gastric Epithelial Cells

Published in The Journal of Experimental Medicine • Feb 21, 2000

Authors:

Momoyo Asahi

Takeshi Azuma

Shigeji Ito

Abstract

Attachment of Helicobacter pylori to gastric epithelial cells induces various cellular responses, including the tyrosine phosphorylation of an unknown 145-kD protein and interleukin 8 production. Here we show that this 145-kD protein is the cagA product of H. pylori, an immunodominant, cytotoxin-ass...

Subject

CagA

Biology

Helicobacter pylori

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