Melanocyte-Specific Expression of the Human Tyrosinase Promoter: Activation by the Microphthalmia Gene Product and Role of the Initiator

J. Bentley, Nicola; Eisen, Timothy; R. Goding, Colin

doi:10.1128/mcb.14.12.7996-8006.1994

Public

Melanocyte-Specific Expression of the Human Tyrosinase Promoter: Activation by the Microphthalmia Gene Product and Role of the Initiator

Published in Molecular and Cellular Biology • Dec 1, 1994

Authors:

Nicola J. Bentley

Timothy Eisen

Colin R. Goding

Abstract

The tyrosinase gene is expressed specifically in melanocytes and the cells of the retinal pigment epithelium, which together are responsible for skin, hair, and eye color. By using a combination of DNase I footprinting and band shift assays coupled with mutagenesis of specific DNA elements, we exami...

Subject

Melanocyte

Tyrosinase

Microphthalmia-associated transcription factor

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