The Forkhead Transcription Factor FoxO Regulates Transcription of p27 <i>Kip1</i> and Bim in Response to IL-2

Ståhl, Marie; F. Dijkers, Pascale; J.P.L. Kops, Geert; M.A. Lens, Susanne; J. Coffer, Paul; Burgering, Boudewijn; H. Medema, René

doi:10.4049/jimmunol.168.10.5024

Public

The Forkhead Transcription Factor FoxO Regulates Transcription of p27 Kip1 and Bim in Response to IL-2

Published in The Journal of Immunology • May 1, 2002

Authors:

Marie Ståhl

Pascale F. Dijkers

Geert J.P.L. Kops

Abstract

The cytokine IL-2 plays a very important role in the proliferation and survival of activated T cells. These effects of IL-2 are dependent on signaling through the phosphatidylinositol 3-kinase (PI3K) pathway. We and others have shown that PI3K, through activation of protein kinase B/Akt, inhibits tr...

Subject

FOXO3

Forkhead Transcription Factors

FOXO1

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!