Distinct Epidermal Growth Factor Receptor and <i>KRAS</i> Mutation Patterns in Non–Small Cell Lung Cancer Patients with Different Tobacco Exposure and Clinicopathologic Features

Yee San Tam, Issan; Ping Chung, Lap; Sing Suen, Wai; Wang, Elaine; Chun Mei Wong, May; Keung Ho, Kok; Kit Lam, Wah; Wah Chiu, Shui; Girard, Luc; D. Minna, John; F. Gazdar, Adi; Pik Wong, Maria

doi:10.1158/1078-0432.ccr-05-1981

Public

Distinct Epidermal Growth Factor Receptor and KRAS Mutation Patterns in Non–Small Cell Lung Cancer Patients with Different Tobacco Exposure and Clinicopathologic Features

Published in Clinical Cancer Research • Mar 1, 2006

Authors:

Issan Yee San Tam

Lap Ping Chung

Wai Sing Suen

Abstract

PURPOSE: This study evaluated the mutational profile of epidermal growth factor receptor (EGFR) and KRAS in non-small cell lung cancers in Hong Kong and determined their relation with smoking history and other clinicopathologic features. EXPERIMENTAL DESIGN: Mutational profile of exons 18 to 21 of E...

Subject

KRAS

Epidermal growth factor receptor

Adenocarcinoma

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