Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

C. de Bruin, Elza; McGranahan, Nicholas; Mitter, Richard; Salm, Max; C. Wedge, David; Yates, Lucy; Jamal-Hanjani, Mariam; Shafi, Seema; Murugaesu, Nirupa; J. Rowan, Andrew; Grönroos, Eva; A. Muhammad, Madiha; Horswell, Stuart; Gerlinger, Marco; Varela, Ignacio; Jones, David; Marshall, John; Voet, Thierry; Van Loo, Peter; M. Rassl, Doris; C. Rintoul, Robert; M. Janes, Sam; Lee, Siow-Ming; Forster, Martin; Ahmad, Tanya; Lawrence, David; Falzon, Mary; Capitanio, Arrigo; T. Harkins, Timothy; C. Lee, Clarence; Tom, Warren; Teefe, Enock; Chen, Shann-Ching; Begum, Sharmin; Rabinowitz, Adam; Phillimore, Benjamin; Spencer-Dene, Bradley; Stamp, Gordon; Szallasi, Zoltan; Matthews, Nik; Stewart, Aengus; Campbell, Peter; Swanton, Charles

doi:10.1126/science.1253462

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Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

Shared by NobleBlocks on Oct 10, 2014 • 12:00 AM UTC

Authors:

Elza C. de Bruin

Nicholas McGranahan

Richard Mitter

Abstract

Spatial and temporal dissection of the genomic changes occurring during the evolution of human non–small cell lung cancer (NSCLC) may help elucidate the basis for its dismal prognosis. We sequenced 25 spatially distinct regions from seven operable NSCLCs and found evidence of branched evolution, wit...

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