DNA Binding Site Selection of Dimeric and Tetrameric Stat5 Proteins Reveals a Large Repertoire of Divergent Tetrameric Stat5a Binding Sites

Soldaini, Elisabetta; John, Susan; Moro, Stefano; Bollenbacher, Julie; Schindler, Ulrike; J. Leonard, Warren

doi:10.1128/mcb.20.1.389-401.2000

Public

DNA Binding Site Selection of Dimeric and Tetrameric Stat5 Proteins Reveals a Large Repertoire of Divergent Tetrameric Stat5a Binding Sites

Published in Molecular and Cellular Biology • Jan 1, 2000

Authors:

Elisabetta Soldaini

Susan John

Stefano Moro

Abstract

We have defined the optimal binding sites for Stat5a and Stat5b homodimers and found that they share similar core TTC(T/C)N(G/A)GAA interferon gamma-activated sequence (GAS) motifs. Stat5a tetramers can bind to tandemly linked GAS motifs, but the binding site selection revealed that tetrameric bindi...

Subject

Tetramer

Biology

Binding site

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