Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

I. Itani, Samar; B. Ruderman, Neil; Schmieder, Frank; Boden, Guenther

doi:10.2337/diabetes.51.7.2005

Public

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

Published in Diabetes • Jul 1, 2002

Authors:

Samar I. Itani

Neil B. Ruderman

Frank Schmieder

Abstract

The possibility that lipid-induced insulin resistance in human muscle is related to alterations in diacylglycerol (DAG)/protein kinase C (PKC) signaling was investigated in normal volunteers during euglycemic-hyperinsulinemic clamping in which plasma free fatty acid (FFA) levels were increased by a ...

Subject

Diacylglycerol kinase

Internal medicine

Endocrinology

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