Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma

Hose, Dirk; Rème, Thierry; Hielscher, Thomas; Moreaux, Jérôme; Messner, Torbjörn; Seckinger, Anja; Benner, Axel; D. Shaughnessy, John; Barlogie, Bart; Zhou, Yiming; Hillengaß, Jens; Bertsch, Uta; Neben, Kai; Möhler, Th.; Rossi, Jean‐François; Jauch, A.; Klein, Barbara; Goldschmidt, H.

doi:10.3324/haematol.2010.030296

Public

Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma

Published in Haematologica • Sep 30, 2010

Authors:

Dirk Hose

Thierry Rème

Thomas Hielscher

Abstract

BACKGROUND: Proliferation of malignant plasma cells is a strong adverse prognostic factor in multiple myeloma and simultaneously targetable by available (e.g. tubulin polymerase inhibitors) and upcoming (e.g. aurora kinase inhibitors) compounds. DESIGN AND METHODS: We assessed proliferation using ge...

Subject

Multiple myeloma

Beta-2 microglobulin

Internal medicine

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