Genomic Instability in Mice Lacking Histone H2AX

Celeste, Arkady; Petersen, Simone; Romanienko, Peter; Fernández-Capetillo, Óscar; Tang Chen, Hua; A. Sedelnikova, Olga; Reina‐San‐Martin, Bernardo; Coppola, Vincenzo; Meffre, Eric; J. Difilippantonio, Michael; E. Redon, Christophe; R. Pilch, Duane; Olaru, Alexandru; Eckhaus, Michael; Daniel Camerini‐Otero, R.; Tessarollo, Lino; Livák, Ferenc; Manova, Katia; M. Bonner, William; C. Nussenzweig, Michel; Nussenzweig, André

doi:10.1126/science.1069398

Public

Genomic Instability in Mice Lacking Histone H2AX

Published in Science • May 3, 2002

Authors:

Arkady Celeste

Simone Petersen

Peter Romanienko

Abstract

Higher order chromatin structure presents a barrier to the recognition and repair of DNA damage. Double-strand breaks (DSBs) induce histone H2AX phosphorylation, which is associated with the recruitment of repair factors to damaged DNA. To help clarify the physiological role of H2AX, we targeted H2A...

Subject

Genome instability

RAD51

DNA damage

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