Impaired nitric oxide bioavailability and <scp>l</scp> -arginine–reversible endothelial dysfunction in adults with falciparum malaria

Wen Yeo, Tsin; A. Lampah, Daniel; Gitawati, Retno; Tjitra, Emiliana; Kenangalem, Enny; McNeil, Yvette; J. Darcy, Christabelle; L. Granger, Donald; Brice Weinberg, J.; K. Lopansri, Bert; N. Price, Ric; B. Duffull, Stephen; S. Celermajer, David; M. Anstey, Nicholas

doi:10.1084/jem.20070819

Public

Impaired nitric oxide bioavailability and l -arginine–reversible endothelial dysfunction in adults with falciparum malaria

Published in The Journal of Experimental Medicine • Oct 22, 2007

Authors:

Tsin Wen Yeo

Daniel A. Lampah

Retno Gitawati

Abstract

Severe falciparum malaria (SM) is associated with tissue ischemia related to cytoadherence of parasitized erythrocytes to microvascular endothelium and reduced levels of NO and its precursor, l-arginine. Endothelial function has not been characterized in SM but can be improved by l-arginine in cardi...

Subject

Endothelial dysfunction

Medicine

Endothelial activation

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