Clinical application of massively parallel sequencing‐based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11 105 pregnancies with mixed risk factors

Dan, Shan; Wang, Wei; Ren, Jinghui; Li, Yali; Hu, Hua; Xu, Zhengfeng; Kin Lau, Tze; Xie, Jianhong; Zhao, Weihua; Huang, Hefeng; Xie, Jiansheng; Sun, Luming; Zhang, Xiaohong; Zhang, Xiaohong; Wang, Weipeng; Liao, Shixiu; Qiang, Rong; Cao, Jiangxia; Zhang, Qiufang; Zhou, Yulin; Zhu, Haiyan; Zhong, Mei; Guo, Yi; Lin, Linhua; Gao, Zhiying; Yao, Hong; Zhang, Hong‐Yun; Zhao, Lijian; Jiang, Fuman; Chen, Fang; Jiang, Hui; Li, Songgang; Li, Yingrui; Wang, Jun; Wang, Jian; Duan, Tao; Su, Yue; Zhang, Xiuqing; Zhang, Xiuqing

doi:10.1002/pd.4002

Public

Clinical application of massively parallel sequencing‐based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11 105 pregnancies with mixed risk factors

Published in Prenatal Diagnosis • Nov 9, 2012

Authors:

Shan Dan

Wei Wang

Jinghui Ren

Abstract

OBJECTIVE: To report the performance of massively parallel sequencing (MPS) based prenatal noninvasive fetal trisomy test based on cell-free DNA sequencing from maternal plasma in a routine clinical setting in China. METHOD: The MPS-based test was offered as a prenatal screening test for trisomies 2...

Subject

Trisomy

Massive parallel sequencing

Medicine

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