Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, Mamta; Peng Koh, Kian; Shen, Yinghua; A. Pastor, William; S. Bandukwala, Hozefa; Brudno, Yevgeny; Agarwal, Suneet; M. Iyer, Lakshminarayan; R. Liu, David; Aravind, L.; Rao, Anjana

doi:10.1126/science.1170116

Public

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Published in Science • Apr 16, 2009

Authors:

Mamta Tahiliani

Kian Peng Koh

Yinghua Shen

Abstract

Methylation Mediation Methylation of cytosine bases, 5-methylcytosine (5mC), in DNA plays an important regulatory role in mammalian genomes. Methylation patterns are often inherited across generations, but they can also be dynamic, suggesting that active DNA demethylation pathways exist. One such pa...

Subject

5-Hydroxymethylcytosine

5-Methylcytosine

DNA demethylation

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!