Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

V. Holmes, Michael; Dale, Caroline; Zuccolo, Luisa; J. Silverwood, Richard; Guo, Yanfei; Ye, Z.; Prieto‐Merino, David; Dehghan, Abbas; Trompet, Stella; Wong, Andrew; Cavadino, Alana; Drogan, Dagmar; Padmanabhan, Sandosh; Li, Simon; Yesupriya, Ajay; Leusink, Maarten; Sundström, Johan; A. Hubáček, Jaroslav; Pikhart, Hynek; I. Swerdlow, Daniel; G. Panayiotou, Andrie; A. Borinskaya, S.; Finan, Chris; Shah, Sonia; Kuchenbaecker, Karoline; Shah, Tina; Engmann, Jorgen; Folkersen, Lasse; Eriksson, Per; Ricceri, Fulvio; Melander, Olle; Sacerdote, Carlotta; M. Gamble, Dale; Rayaprolu, Sruti; A. Ross, Owen; McLachlan, S.; Vikhireva, Olga; Sluijs, Ivonne; Scott, R.A.; Adámková, Věra; Flicker, Leon; M. van Bockxmeer, F.; Power, Chris; Marques‐Vidal, Pedro; W Meade, T; Marmot, Michael; M. Ferro, José; Paulos-Pinheiro, S.; E. Humphries, Steve; J. Talmud, Philippa; Mateo Leach, Irene; Verweij, Niek; Linneberg, Allan; Skaaby, Tea; A. Doevendans, Pieter; J. Cramer, Maarten; van der Harst, Pim; H. Klungel, Olaf; F. Dowling, Nicole; F. Dominiczak, Anna; Kumari, Meena; Nicolaides, Andrew; Weikert, Cornelia; Boeing, Heiner; Ebrahim, Shah; R. Gaunt, Tom; F. Price, Jackie; Lannfelt, L.; Peasey, Anne; Kubínová, Růžena; Pajak, A.; Malyutina, Sofia; I. Voevoda, M.; Tamošiūnas, Algirdas; H. Maitland‐van der Zee, Anke; E. Norman, Paul; J. Hankey, Graeme; Bergmann, Michael; Hofman, Amy; H. Franco, Oscar; Cooper, J.; Palmen, Jutta; Spiering, Wilko; A. de Jong, Pim; Kuh, Diana; Hardy, Rebecca; G. Uitterlinden, André; Arfan Ikram, M.; Ford, Ian; Hyppönen, Elina; P. Almeida, Osvaldo; J. Wareham, Nicholas; Khaw, K.-T.; Hamsten, Anders; Lotte N. Husemoen, Lise; Tjønneland, Anne; Schurmann Tolstrup, Janne; B. Rimm, Eric; W. J. Beulens, Joline; M. Monique Verschuren, W.; Charlotte Onland‐Moret, N.; H. Hofker, Marten; Goya Wannamethee, S.; H. Whincup, Peter; Morris, Richard; M. Vicente, Astrid; Watkins, Hugh; Farrall, Martin; Wouter Jukema, J.; F. Meschia, James; Adrienne Cupples, L.; J. Sharp, Stephen; Fornage, M.; Kooperberg, Charles; Z. LaCroix, Andrea; Dai, Jiyan; B. Lanktree, Matthew; S. Siscovick, David; Jorgenson, Eric; Spring, Bonnie; Coresh, Josef; R. Li, Y.; G. Buxbaum, Sarah; J. Schreiner, Pamela; Curtis Ellison, R.; Y. Tsai, Michael; R. Patel, Sanjay; Redline, Susan; D. Johnson, Andrew; C. Hoogeveen, Ron; Hakonarson, H.; I. Rotter, Jerome; Boerwinkle, Eric; I. W. de Bakker, Paul; Kivimäki, Mika; W. Asselbergs, Folkert; Sattar, Naveed; A. Lawlor, Debbie; C. Whittaker, John; Davey Smith, George; Mukamal, K.; M. Psaty, Bruce; Wilson, James; A. Lange, Leslie; Hamidovic, Ajna; D. Hingorani, Aroon; G. Nordestgaard, Børge; Bobák, Martin; A. Leon, David; Langenberg, Claudia; Palmer, Tom; P. Reiner, Alex; J. Keating, Brendan; Dudbridge, Frank; P. Casas, J.

doi:10.1136/bmj.g4164

Public

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Published in BMJ • Jul 10, 2014

Authors:

Michael V. Holmes

Caroline Dale

Luisa Zuccolo

Abstract

OBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PARTICIPANTS: 261 991 individuals of European descen...

Subject

Association (psychology)

Disease

Mendelian inheritance

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