Loss of Phosphatase and Tensin Homolog or Phosphoinositol-3 Kinase Activation and Response to Trastuzumab or Lapatinib in Human Epidermal Growth Factor Receptor 2–Overexpressing Locally Advanced Breast Cancers

Dave, Bhuvanesh; Migliaccio, Ilenia; Carolina Gutierrez, M.; Wu, Meng-Fen; C. Chamness, Gary; Wong, Helen; Narasanna, Archana; Chakrabarty, Anindita; G. Hilsenbeck, Susan; Huang, Jian; Rimawi, Mothaffar; Schiff, Rachel; Arteaga, Carlos; Kent Osborne, C.; C. Chang, Jenny

doi:10.1200/jco.2009.27.7814

Public

Loss of Phosphatase and Tensin Homolog or Phosphoinositol-3 Kinase Activation and Response to Trastuzumab or Lapatinib in Human Epidermal Growth Factor Receptor 2–Overexpressing Locally Advanced Breast Cancers

Shared by NobleBlocks on Jan 10, 2011 • 12:00 AM UTC

Authors:

Bhuvanesh Dave

Ilenia Migliaccio

M. Carolina Gutierrez

Abstract

Purpose Phosphatase and tensin homolog (PTEN) loss or activating mutations of phosphoinositol-3 (PI3) kinase (PIK3CA) may be associated with trastuzumab resistance. Trastuzumab, the humanized human epidermal growth factor receptor 2 (HER2) monoclonal antibody, and lapatinib, an epidermal growth fact...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!