Loss of Phosphatase and Tensin Homolog or Phosphoinositol-3 Kinase Activation and Response to Trastuzumab or Lapatinib in Human Epidermal Growth Factor Receptor 2–Overexpressing Locally Advanced Breast Cancers

Dave, Bhuvanesh; Migliaccio, Ilenia; Gutierrez, Maya; Wu, Meng-Fen; C. Chamness, Gary; Wong, Helen; Narasanna, Archana; Chakrabarty, Anindita; G. Hilsenbeck, Susan; Huang, Jian; F. Rimawi, Mothaffar; Schiff, Rachel; L. Arteaga, Carlos; Kent Osborne, C.; C. Chang, Jenny

doi:10.1200/jco.2009.27.7814

Public

Loss of Phosphatase and Tensin Homolog or Phosphoinositol-3 Kinase Activation and Response to Trastuzumab or Lapatinib in Human Epidermal Growth Factor Receptor 2–Overexpressing Locally Advanced Breast Cancers

Published in Journal of Clinical Oncology • Dec 7, 2010

Authors:

Bhuvanesh Dave

Ilenia Migliaccio

Maya Gutierrez

Abstract

PURPOSE: Phosphatase and tensin homolog (PTEN) loss or activating mutations of phosphoinositol-3 (PI3) kinase (PIK3CA) may be associated with trastuzumab resistance. Trastuzumab, the humanized human epidermal growth factor receptor 2 (HER2) monoclonal antibody, and lapatinib, an epidermal growth fac...

Subject

Trastuzumab

Lapatinib

PTEN

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