Dimethylaminoethyl methacrylate copolymer-siRNA nanoparticles for silencing a therapeutically relevant gene in macrophages

Jain, Ratnesh; Dandekar, Prajakta; Loretz, Brigitta; Koch, Marcus; Lehr, Claus‐Michael

doi:10.1039/c4md00490f

Public

Dimethylaminoethyl methacrylate copolymer-siRNA nanoparticles for silencing a therapeutically relevant gene in macrophages

Published in MedChemComm • Jan 1, 2015

Authors:

Ratnesh Jain

Prajakta Dandekar

Brigitta Loretz

Abstract

DMC nanoparticles target Bfl1/A1 gene in lung macrophages and effective silencing of Bfl1/A1 gene by DMC nanoparticles paves the way for research on alternative treatment strategies for tuberculosis.

Subject

Gene silencing

Methacrylate

Copolymer

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