DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells

Tassaneetrithep, Boonrat; H. Burgess, Timothy; Granelli‐Piperno, Angela; Trumpfheller, Christine; Finke, Jennifer; Sun, Wellington; A. Eller, Michael; Pattanapanyasat, Kovit; Sarasombath, S; L. Birx, Deborah; M. Steinman, Ralph; J. Schlesinger, Sarah; Marovich, Mary

doi:10.1084/jem.20021840

Public

DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells

Published in The Journal of Experimental Medicine • Apr 7, 2003

Authors:

Boonrat Tassaneetrithep

Timothy H. Burgess

Angela Granelli‐Piperno

Abstract

Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become sus...

Subject

DC-SIGN

Dengue virus

Virology

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