Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders

Novarino, Gaia; G. Fenstermaker, Ali; S. Zaki, Maha; Hofree, Matan; L. Silhavy, Jennifer; D. Heiberg, Andrew; Abdellateef, Mostafa; Rosti, Basak; Scott, Eric; Mansour, Lobna; Masri, Amira; Kayserili, Hulya; Y. Al-Aama, Jumana; M. H. Abdel-Salam, Ghada; Karminejad, Ariana; Kara, Majdi; Kara, Bulent; Bozorgmehri, Bita; Ben-Omran, Tawfeg; Mojahedi, Faezeh; Gamal El Din Mahmoud, Iman; Bouslam, Naima; Bouhouche, Ahmed; Benomar, Ali; Hanein, Sylvain; Raymond, Laure; Forlani, Sylvie; Mascaro, Massimo; Selim, Laila; Shehata, Nabil; Al-Allawi, Nasir; Bindu, P.S.; Azam, Matloob; Gunel, Murat; Caglayan, Ahmet; Bilguvar, Kaya; Tolun, Aslihan; Y. Issa, Mahmoud; Schroth, Jana; G. Spencer, Emily; O. Rosti, Rasim; Akizu, Naiara; K. Vaux, Keith; Johansen, Anide; A. Koh, Alice; Megahed, Hisham; Durr, Alexandra; Brice, Alexis; Stevanin, Giovanni; B. Gabriel, Stacy; Ideker, Trey; G. Gleeson, Joseph

doi:10.1126/science.1247363

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Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders

Shared by NobleBlocks on Jan 28, 2014 • 12:00 AM UTC

Authors:

Gaia Novarino

Ali G. Fenstermaker

Maha S. Zaki

Abstract

Neurodegenerative Genetics The underlying genetics of neurodegenerative disorders tend not to be well understood. Novarino et al. (p. 506 ; see the Perspective by Singleton ) investigated the underlying genetics of hereditary spastic paraplegia (HSP), a human neurodegenerative disease, by sequencing...

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