Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

L. Carey, Andrew; R. Steinberg, Gregory; Lance Macaulay, S.; G. Thomas, Walter; G. Holmes, Anna; Ramm, Georg; Prelovsek, Oja; Hohnen-Behrens, Cordula; J. Watt, Matthew; E. James, David; E. Kemp, Bruce; Klarlund Pedersen, Bente; A. Febbraio, Mark

doi:10.2337/db05-1404

Public

Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

Published in Diabetes • Sep 26, 2006

Authors:

Andrew L. Carey

Gregory R. Steinberg

S. Lance Macaulay

Abstract

Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known regarding the effects of IL-6 on insulin sensitivity in humans in vivo. Here, we show that IL-6 infusion increases glucose disposal without affecting the complete suppression of endogenous glucose production d...

Subject

Glucose uptake

GLUT4

Internal medicine

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