Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

Sathasivam, Kirupa; Lane, Amin; Legleiter, Justin; Warley, Alice; Woodman, Ben; Finkbeiner, Steven; Paganetti, Paolo; J. Muchowski, Paul; M. Wilson, Stuart; P. Bates, Gillian

doi:10.1093/hmg/ddp467

Public

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

Published in Human Molecular Genetics • Oct 12, 2009

Authors:

Kirupa Sathasivam

Amin Lane

Justin Legleiter

Abstract

Huntington's disease (HD) is a late-onset neurodegenerative disorder that is characterized neuropathologically by the presence of neuropil aggregates and nuclear inclusions. However, the profile of aggregate structures that are present in the brains of HD patients or of HD mouse models and the relat...

Subject

Huntingtin

Huntington's disease

Biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!