A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene <i>BRCA1</i>

Miki, Yoshio; Swensen, Jeffrey; Shattuck-Eidens, Donna; Andrew Futreal, P.; Harshman, Keith; V. Tavtigian, Sean; Liu, Qingyun; Cochran, Charles; Michelle Bennett, L.; Ding, Wei; Bell, Russell; Rosenthal, Judith; E. Hussey, Charles; V. Tran, Thanh; McClure, Melody; A. Frye, Cheryl; Hattier, Tom; Phelps, Robert; C. Haugen, Astrid; L. Katcher, Harold; Yakumo, Kazuko; Gholami, Zahra; J. Shaffer, Daniel; Stone, Steven; R Bayer, Steven; Wray, Christian; Bogden, Robert; Dayananth, Priya; H. Ward, John; N. Tonin, Patricia; A. Narod, Steven; K. Bristow, Pam; H. Norris, Frank; M. Helvering, Leah; Morrison, P.; R. Rosteck, Paul; Lai, Mei; Carl Barrett, J.; M. Lewis, Cathryn; L. Neuhausen, Susan; Cannon‐Albright, Lisa; E. Goldgar, David; W. Wiseman, Roger; Kamb, Alexander; H. Skolnick, Mark

doi:10.1126/science.7545954

Public

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

Published in Science • Oct 7, 1994

Authors:

Yoshio Miki

Jeffrey Swensen

Donna Shattuck-Eidens

Abstract

A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods. Probable predisposing mutations have been detected in five of eight kindreds presumed to segregate BRCA1 susceptibility alleles. The muta...

Subject

Missense mutation

Gene

Genetics

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