Suppression of Tumor Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling

He, Yulong; Kozaki, Ken‐ichi; Kärpänen, Terhi; Koshikawa, Katsumi; Ylä‐Herttuala, Seppo; Takahashi, Takashi; Alitalo, Kari

doi:10.1093/jnci/94.11.819

Public

Suppression of Tumor Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling

Published in JNCI Journal of the National Cancer Institute • Jun 5, 2002

Authors:

Yulong He

Ken‐ichi Kozaki

Terhi Kärpänen

Abstract

BACKGROUND: Vascular endothelial growth factor C (VEGF-C) stimulates tumor lymphangiogenesis (i.e., formation of lymphatic vessels) and metastasis to regional lymph nodes by interacting with VEGF receptor 3 (VEGFR-3). We sought to determine whether inhibiting VEGFR-3 signaling, and thus tumor lympha...

Subject

Lymphangiogenesis

Transfection

Lymph

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