Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

G. Winkler, Ingrid; A. Sims, Natalie; R. Pettit, Allison; Barbier, Valérie; Nowlan, Bianca; Helwani, Falak; J. Poulton, Ingrid; van Rooijen, Nico; A. Alexander, Kylie; J. Raggatt, Liza; Lévesque, Jean-Pierre

doi:10.1182/blood-2009-11-253534

Public

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

Published in Blood • Aug 17, 2010

Authors:

Ingrid G. Winkler

Natalie A. Sims

Allison R. Pettit

Abstract

In the bone marrow, hematopoietic stem cells (HSCs) reside in specific niches near osteoblast-lineage cells at the endosteum. To investigate the regulation of these endosteal niches, we studied the mobilization of HSCs into the bloodstream in response to granulocyte colony-stimulating factor (G-CSF)...

Subject

Haematopoiesis

Bone marrow

Stem cell

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