A Phase I, Dose-Finding Study in Patients with Advanced Solid Malignancies of the Oral γ-Secretase Inhibitor PF-03084014

A. Messersmith, Wells; I. Shapiro, Geoffrey; M. Cleary, James; Jimeno, Antonio; Dasari, Arvind; Huang, Bo; Naveed Shaik, M.; Cesari, Rossano; Zheng, Xianxian; M. Reynolds, Jennifer; A. English, Patricia; R. McLachlan, Karen; A. Kern, Kenneth; M. LoRusso, Patricia

doi:10.1158/1078-0432.ccr-14-0607

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A Phase I, Dose-Finding Study in Patients with Advanced Solid Malignancies of the Oral γ-Secretase Inhibitor PF-03084014

Shared by NobleBlocks on Jan 1, 2015 • 12:00 AM UTC

Authors:

Wells A. Messersmith

Geoffrey I. Shapiro

James M. Cleary

Abstract

Abstract Purpose: To estimate the maximum tolerated dose (MTD) for continuous oral administration of the γ-secretase inhibitor PF-03084014, determine the recommended phase II dose (RP2D), and evaluate safety and preliminary activity in patients with advanced solid tumors. Experimental Design: This o...

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