Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease

Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators, The

doi:10.1056/nejmoa060900

Public

Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease

Published in New England Journal of Medicine • Mar 12, 2006

Authors:

The Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators

Abstract

BACKGROUND: In observational studies, lower homocysteine levels are associated with lower rates of coronary heart disease and stroke. Folic acid and vitamins B6 and B12 lower homocysteine levels. We assessed whether supplementation reduced the risk of major cardiovascular events in patients with vas...

Subject

Medicine

Placebo

Relative risk

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