Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic

Leist, Marcel; Ghezzi, Pietro; Grasso, Giovanni; Bianchi, Roberto; Villa, Pia; Fratelli, Maddalena; Savino, Costanza; Bianchi, Marina; Nielsen, Jacob; Gerwien, Jens; Kallunki, Pekka; Kirstine Larsen, Anna; Helboe, Lone; Christensen, Søren; Østergaard Pedersen, Lars; Nielsen, Mette; Torup, Lars; N. Sager, Thomas; Sfacteria, Alessandra; Erbayraktar, Serhat; Erbayraktar, Zübeyde; Gökmen, Necati; Yılmaz, Osman; Cerami-Hand, Carla; W Xie, Q; R. Coleman, Thomas; Cerami, Anthony; Brines, Michael

doi:10.1126/science.1098313

Public

Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic

Published in Science • Jul 8, 2004

Authors:

Marcel Leist

Pietro Ghezzi

Giovanni Grasso

Abstract

Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor subtype-selective ligands allowing the separation of EPO's bioactivities at the cellular level and in animals. Carbamylated EPO (CEPO) or certain EPO mutan...

Subject

Erythropoietin

Erythropoietin receptor

Haematopoiesis

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