Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

J. Stephens, Philip; Greenman, Chris; Fu, Beiyuan; Yang, Fengtang; R. Bignell, Graham; Mudie, Laura; Pleasance, Erin; Wai Lau, King; Beare, David; Stebbings, Lucy; McLaren, Stuart; Lin, Meng‐Lay; J. McBride, David; Varela, Ignacio; Nik‐Zainal, Serena; Leroy, Catherine; Jia, Mingming; Menzies, Andrew; P. Butler, Adam; W. Teague, Jon; A. Quail, Michael; H. Burton, John; Swerdlow, Harold; P. Carter, Nigel; Morsberger, Laura; A. Iacobuzio–Donahue, Christine; Follows, George; R. Green, Anthony; M. Flanagan, Adrienne; R. Stratton, Michael; Andrew Futreal, P.; J. Campbell, Peter

doi:10.1016/j.cell.2010.11.055

Public

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

Published in Cell • Jan 1, 2011

Authors:

Philip J. Stephens

Chris Greenman

Beiyuan Fu

Abstract

Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in...

Subject

Biology

Event (particle physics)

Cancer

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