Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product

Pasquier, Benoit; Yin, Luo; Fondanèche, Marie‐Claude; Relouzat, Francis; Bloch‐Queyrat, Coralie; Lambert, Nathalie; Fischer, Alain; de Saint Basile, Geneviève; Latour, Sylvain

doi:10.1084/jem.20042432

Public

Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product

Published in The Journal of Experimental Medicine • Feb 28, 2005

Authors:

Benoit Pasquier

Luo Yin

Marie‐Claude Fondanèche

Abstract

SAP is an adaptor protein expressed in T cells and natural killer cells. It plays a critical role in immunity, as it is mutated in humans with X-linked lymphoproliferative syndrome (XLP), a fatal immunodeficiency characterized by an abnormal response to Epstein-Barr virus (EBV) infection. SAP intera...

Subject

Natural killer T cell

Biology

Immunology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!