Neuroprotection mediated by changes in the endothelial actin cytoskeleton.

U, Laufs; M, Endres; N, Stagliano; S, Amin-Hanjani; DS, Chui; SX, Yang; T, Simoncini; M, Yamada; E, Rabkin; PG, Allen; PL, Huang; M, Böhm; FJ, Schoen; MA, Moskowitz; JK, Liao

doi:10.1172/jci9639

Public

Neuroprotection mediated by changes in the endothelial actin cytoskeleton.

Shared by NobleBlocks on Jul 1, 2000 • 12:00 AM UTC

Authors:

Laufs U

Endres M

Stagliano N

Abstract

Cerebral blood flow is regulated by endothelium-derived nitric oxide (NO), and endothelial NO synthase-deficient (eNOS-deficient; eNOS(-/-)) mice develop larger cerebral infarctions following middle cerebral artery (MCA) occlusion. We report that disruption of Rho-mediated endothelial actin cytoskel...

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