Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

) increased H4K12 and H3K9 histone acetylation in primary mouse neuronal cell culture assays, in the hippocampus of CK-p25 mice, a model of neurodegenerative disease, and rescued the associated memory deficits of these mice in a cognition behavioural model. These studies demonstrate for the first ti... View More