Monomethylation of Histone H4-Lysine 20 Is Involved in Chromosome Structure and Stability and Is Essential for Mouse Development

Oda, Hisanobu; Okamoto, Ikuhiro; Murphy, Niall; Chu, Jianhua; M. Price, Sandy; M. Shen, Michael; Elena Torres-Padilla, Marı́a; Heard, Édith; Reinberg, Danny

doi:10.1128/mcb.01768-08

Public

Monomethylation of Histone H4-Lysine 20 Is Involved in Chromosome Structure and Stability and Is Essential for Mouse Development

Published in Molecular and Cellular Biology • Feb 18, 2009

Authors:

Hisanobu Oda

Ikuhiro Okamoto

Niall Murphy

Abstract

PR-Set7/Set8/KMT5A is the sole enzyme known to catalyze monomethylation of histone H4 lysine 20 (H4K20) and is present only in multicellular organisms that compact a large fraction of their DNA. We found that mouse embryos that are homozygous null mutants for the gene PR-Set7 display early embryonic...

Subject

Biology

Histone H4

Histone methyltransferase

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