Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial

I. Brunner, Hermine; Ruperto, Nicolino; Żuber, Zbigniew; Keane, Caroline; Harari, Olivier; Kenwright, Andrew; Lü, Peng; Cuttica, Rubén; Keltsev, Vladimir; Machado Xavier, Ricardo; Calvo, Inmaculada; П. Никишина, И.; Rubio‐Pérez, Nadina; Alexeeva, Е.I.; Chasnyk, Vyacheslav; Horneff, Gerd; Opoka‐Winiarska, Violetta; Quartier, Pierre; A. Silva, Clóvis; D. Silverman, Earl; Spindler, Alberto; Baildam, Eileen; Luz Gámir Gámir, María; Martin, Alan; Rietschel, Christoph; Siri, Daniel; Smolewska, Elżbieta; J. Lovell, Daniel; Martini, Alberto; De Benedetti, Fabrizio; Espada, Graciela; Allen, Roger; Chaitow, Jeffrey; Joos, Rik; Wouters, Carine; Knupp, Sheila; Sztajnbok, Flavio; Cabral, David; Houghton, Kristin; Roth, Johannes; Schmeling, Heinrike; Job-Deslandre, Chantal; Jorgensen, Christian; Kone Paut, Isabelle; Minden, Kirsten; Weller-Heinemann, Frank; Gerloni, Valeria; Zulian, Francesco; Burgos-Vargas, Ruben; Duarte Salazar, Carolina; Solis-Vallejo, Eunice; Calvo, Armando; Chavez, José; Ferrandiz Zavaler, Manuel; Gruenpeter, Anna; Kobusinska, Katarzyna; Sarychev, Alexey; Zholobova, Elena; Ramanan, Athimalaipet; Woo, Patricia; Goodman, Steven; Gedalia, Abraham; Kimura, Yukiko; Onel, Karen; Schikler, Kenneth

doi:10.1136/annrheumdis-2014-205351

Public

Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial

Published in Annals of the Rheumatic Diseases • May 17, 2014

Authors:

Hermine I. Brunner

Nicolino Ruperto

Zbigniew Żuber

Abstract

OBJECTIVE: To evaluate the interleukin-6 receptor inhibitor tocilizumab for the treatment of patients with polyarticular-course juvenile idiopathic arthritis (pcJIA). METHODS: This three-part, randomised, placebo-controlled, double-blind withdrawal study (NCT00988221) included patients who had activ...

Subject

Tocilizumab

Medicine

Placebo

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