In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes.

J Lachmann, Helen; Lowe, Philip; Daniela Felix, Sandra; Rordorf, Christiane; Leslie, Kieron; Madhoo, Sheril; Wittkowski, Helmut; Bek, Stephan; Hartmann, Nicole; Bosset, Sophie; N Hawkins, Philip; Jung, Thomas

doi:10.1084/jem.20082481

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In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes.

Shared by NobleBlocks on May 11, 2009 • 12:00 AM UTC

Authors:

Helen J Lachmann

Philip Lowe

Sandra Daniela Felix

Abstract

The investigation of interleukin 1beta (IL-1beta) in human inflammatory diseases is hampered by the fact that it is virtually undetectable in human plasma. We demonstrate that by administering the anti-human IL-1beta antibody canakinumab (ACZ885) to humans, the resulting formation of IL-1beta-antibo...

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