Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species

Atarashi, Koji; Tanoue, Takeshi; Shima, Tatsuichiro; Imaoka, Akemi; Kuwahara, Tomomi; Momose, Yoshika; Cheng, Genhong; Yamasaki, Sho; Saito, Takashi; Ohba, Yusuke; Taniguchi, Tadatsugu; Takeda, Kiyoshi; Hori, Shohei; I. Ivanov, Ivaylo; Umesaki, Yoshinori; Itoh, Kikuji; Honda, Kenya

doi:10.1126/science.1198469

Public

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

Published in Science • Dec 23, 2010

Authors:

Koji Atarashi

Takeshi Tanoue

Tatsuichiro Shima

Abstract

CD4(+) T regulatory cells (T(regs)), which express the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show that in mice, T(regs) were most abundant in the colonic mucosa. The spore-forming component of indigenous intestinal microbiota, particularl...

Subject

Indigenous

Clostridium

Microbiology

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