Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: the additive and subtractive effect of the three dopaminergic genes--DRD2, D beta H, and DAT1.

DE, Comings; S, Wu; C, Chiu; RH, Ring; R, Gade; C, Ahn; JP, MacMurray; G, Dietz; D, Muhleman

doi:10.1002/(sici)1096-8628(19960531)67:3<264::aid-ajmg4>3.0.co;2-n

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Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: the additive and subtractive effect of the three dopaminergic genes--DRD2, D beta H, and DAT1.

Shared by NobleBlocks on May 1, 1996 • 12:00 AM UTC

Authors:

Comings DE

Wu S

Chiu C

Abstract

Polymorphisms of three different dopaminergic genes, dopamine D2 receptor (DRD2), dopamine beta-hydroxylase (D beta H), and dopamine transporter (DAT1), were examined in Tourette syndrome (TS) probands, their relatives, and controls. Each gene individually showed a significant correlation with vario...

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