Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: The additive and subtractive effect of the three dopaminergic genes—DRD2, DβH, and DAT1

E. Comings, David; Wu, Shijuan; Chiu, Connie; H. Ring, Robert; Gade, Radhika; Ahn, Chul; P. MacMurray, James; Dietz, George; Muhleman, Donn

doi:10.1002/(sici)1096-8628(19960531)67:3<264::aid-ajmg4>3.0.co;2-n

Public

Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: The additive and subtractive effect of the three dopaminergic genes—DRD2, DβH, and DAT1

Published in American Journal of Medical Genetics • May 31, 1996

Authors:

David E. Comings

Shijuan Wu

Connie Chiu

Abstract

Polymorphisms of three different dopaminergic genes, dopamine D2 receptor (DRD2), dopamine beta-hydroxylase (D beta H), and dopamine transporter (DAT1), were examined in Tourette syndrome (TS) probands, their relatives, and controls. Each gene individually showed a significant correlation with vario...

Subject

Dopaminergic

Dopamine transporter

Attention deficit hyperactivity disorder

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