<i>BRAF/NRAS</i> Mutation Frequencies Among Primary Tumors and Metastases in Patients With Melanoma

Colombino, Maria; Capone, Mariaelena; Lissia, Amelia; Cossu, Antonio; Rubino, Corrado; De Giorgi, Vincenzo; Massi, Daniela; Fonsatti, Ester; Staibano, Stefania; Nappi, Oscar; Pagani, Elena; Casula, Milena; Manca, Antonella; Cristina Sini, Maria; Franco, Renato; Botti, Gerardo; Caracò, Corrado; Mozzillo, Nicola; A. Ascierto, Paolo; Palmieri, Giuseppe

doi:10.1200/jco.2011.41.2452

Public

BRAF/NRAS Mutation Frequencies Among Primary Tumors and Metastases in Patients With Melanoma

Published in Journal of Clinical Oncology • May 21, 2012

Authors:

Maria Colombino

Mariaelena Capone

Amelia Lissia

Abstract

PURPOSE: The prevalence of BRAF, NRAS, and p16CDKN2A mutations during melanoma progression remains inconclusive. We investigated the prevalence and distribution of mutations in these genes in different melanoma tissues. PATIENTS AND METHODS: In all, 291 tumor tissues from 132 patients with melanoma ...

Subject

Neuroblastoma RAS viral oncogene homolog

Medicine

Melanoma

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