IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

Kotake, Shigeru; Udagawa, Nobuyuki; Takahashi, Naoyuki; MATSUZAKI, Kenichiro; Itoh, Kanami; Ishiyama, Shigeru; Saito, Seiji; Inoue, Kazuhiko; Kamatani, Naoyuki; T. Gillespie, Matthew; John Martin, T.; Suda, Tatsuo

doi:10.1172/jci5703

Public

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

Published in Journal of Clinical Investigation • May 1, 1999

Authors:

Shigeru Kotake

Nobuyuki Udagawa

Naoyuki Takahashi

Abstract

IL-17 is a newly discovered T cell-derived cytokine whose role in osteoclast development has not been fully elucidated. Treatment of cocultures of mouse hemopoietic cells and primary osteoblasts with recombinant human IL-17 induced the formation of multinucleated cells, which satisfied major criteri...

Subject

Osteoclast

Chemistry

Cell biology

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