Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries

L. Johnson, Jason; J. George, Sarah; C. Newby, Andrew; L. Jackson, Christopher

doi:10.1073/pnas.0506201102

Public

Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries

Published in Proceedings of the National Academy of Sciences • Oct 12, 2005

Authors:

Jason L. Johnson

Sarah J. George

Andrew C. Newby

Abstract

Matrix metalloproteinases (MMPs) are thought to be involved in the growth, destabilization, and eventual rupture of atherosclerotic lesions. Using the mouse brachiocephalic artery model of plaque instability, we compared apolipoprotein E (apoE)/MMP-3, apoE/MMP-7, apoE/MMP-9, and apoE/MMP-12 double k...

Subject

Apolipoprotein E

Matrix metalloproteinase

Gene knockout

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