Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits

Scuteri, Angelo; Sanna, Serena; Chen, Wei‐Min; Uda, Manuela; Albai, Giuseppe; Strait, James; S. Najjar, Samer; Nagaraja, Ramaiah; Orrù, Marco; Usala, Gianluca; Dei, Mariano; Lai, Sandra; Maschio, Andrea; Busonero, Fabio; Mulas, Antonella; Ehret, Georg; A Fink, Ashley; B. Weder, Alan; S Cooper, Richard; Galán, Pilar; Chakravarti, Aravinda; Schlessinger, David; Cao, Antonio; G. Lakatta, Edward; R. Abecasis, Gonçalo

doi:10.1371/journal.pgen.0030115

Public

Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits

Published in PLoS Genetics • Jul 13, 2007

Authors:

Angelo Scuteri

Serena Sanna

Wei‐Min Chen

Abstract

The obesity epidemic is responsible for a substantial economic burden in developed countries and is a major risk factor for type 2 diabetes and cardiovascular disease. The disease is the result not only of several environmental risk factors, but also of genetic predisposition. To take advantage of r...

Subject

Minor allele frequency

Single-nucleotide polymorphism

FTO gene

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