Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

Kim-Hellmuth, Sarah; Becker, Jessica; Bechheim, Matthias; B. Kaiser, Vera; Noursadeghi, Mahdad; Fricker, Nadine; Beier, Esther; Klaschik, Sven; Boor, Peter; Hess, Timo; Hofmann, Andrea; Holdenrieder, S; R. Wendland, Jens; Fröhlich, Holger; Hartmann, Gunther; M. Nöthen, Markus; Müller‐Myhsok, Bertram; Pütz, Benno; Hornung, Veit; Schumacher, Johannes

doi:10.1038/ncomms6236

Public

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

Published in Nature Communications • Oct 20, 2014

Authors:

Sarah Kim-Hellmuth

Jessica Becker

Matthias Bechheim

Abstract

Toll-like receptors (TLRs) play a key role in innate immunity. Apart from their function in host defense, dysregulation in TLR signalling can confer risk to autoimmune diseases, septic shock or cancer. Here we report genetic variants and transcripts that are active only during TLR signalling and con...

Subject

PDGFB

Innate immune system

TLR4

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!