Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (
                    <i>Tlr4</i>
                    )

T. Qureshi, Salman; Larivière, Line; Leveque, Gary; Clermont, Sophie; J. Moore, Karen; Gros, Philippe; Malo, Danielle

doi:10.1084/jem.189.4.615

Public

Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 ( Tlr4 )

Shared by NobleBlocks on Feb 15, 1999 • 12:00 AM UTC

Authors:

Salman T. Qureshi

Line Larivière

Gary Leveque

Abstract

Bacterial lipopolysaccharide (LPS) provokes a vigorous, generalized proinflammatory state in the infected host. Genetic regulation of this response has been localized to the Lps locus on mouse chromosome 4, through study of the C3H/HeJ and C57BL/10ScCr inbred strains. Both C3H/HeJ and C57BL/10ScCr m...

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