Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

Ku, Cheng‐Lung; von Bernuth, Horst; Pïcard, Capucine; Zhang, Shen‐Ying; Chang, Huey-Hsuan; Yang, Kun; Chrabieh, Maya; C. Issekutz, Andrew; K. Cunningham, Coleen; I. Gallin, John; M. Holland, Steven; M. Roifman, Chaim; Ehl, Stephan; Smart, Joanne; L.K. Tang, Mimi; J. Barrat, Franck; Levy, Ofer; R. McDonald, Douglas; K. Day-Good, Noorbibi; L. Miller, Richard; Takada, Hidetoshi; Hara, Toshiro; Al-Hajjar, Sami; Al‐Ghonaium, Abdulaziz; P. Speert, David; Sanlaville, Damien; Li, Xiaoxia; Geissmann, Frédéric; Vivier, Éric; Maródi, László; Garty, Ben-Zion; Chapel, Helen; Rodríguez‐Gallego, Carlos; Bossuyt, Xavier; Abel, Laurent; Puel, Anne; Casanova, Jean‐Laurent

doi:10.1084/jem.20070628

Public

Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

Published in The Journal of Experimental Medicine • Sep 24, 2007

Authors:

Cheng‐Lung Ku

Horst von Bernuth

Capucine Pïcard

Abstract

Human interleukin (IL) 1 receptor-associated kinase 4 (IRAK-4) deficiency is a recently discovered primary immunodeficiency that impairs Toll/IL-1R immunity, except for the Toll-like receptor (TLR) 3- and TLR4-interferon (IFN)-alpha/beta pathways. The clinical and immunological phenotype remains lar...

Subject

Immunology

Toll-like receptor

Immunity

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