Role of human <i>MDR1</i> gene polymorphism in bioavailability and interaction of digoxin, a substrate of P‐glycoprotein

Kurata, Yasuo; Ieiri, Ichiro; Kimura, Miyuki; Morita, Toshihiro; Irie, Shin; Urae, Akinori; Ohdo, Shigehiro; Ohtani, Hisakazu; Sawada, Yasufumi; Higuchi, Shun; Otsubo, Kenji

doi:10.1067/mcp.2002.126177

Public

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P‐glycoprotein

Published in Clinical Pharmacology & Therapeutics • Aug 1, 2002

Authors:

Yasuo Kurata

Ichiro Ieiri

Miyuki Kimura

Abstract

OBJECTIVE: Our objective was to quantitate the contribution of the genetic polymorphism of the human MDR1 gene to the bioavailability and interaction profiles of digoxin, a substrate of P-glycoprotein. METHODS: The pharmacokinetics of digoxin was studied in 15 healthy volunteers, who were divided in...

Subject

Digoxin

Bioavailability

Pharmacokinetics

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