Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2mutation carriers

C. Antoniou, Antonis; Kuchenbaecker, Karoline; Soucy, Penny; Beesley, Jonathan; Chen, Xiaoqing; McGuffog, Lesley; Lee, Andrew; Barrowdale, Daniel; Healey, Sue; M. Sinilnikova, Olga; A. Caligo, Maria; Loman, Niklas; Harbst, Katja; Lindblom, Annika; Arver, Brita; Rosenquist, Richard; Karlsson, Per; Nathanson, Kate; M. Domchek, Susan; Rebbeck, Tim; Jakubowska, Anna; Lubiński, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Złowowcka-Perłowska, Elżbieta; Osório, Ana; Durán, M.; Andrés, Raquel; Benı́tez, Javier; Hamann, Ute; B.L. Hogervorst, Frans; A. van Os, Theo; Verhoef, Senno; Meijers‐Heijboer, Hanne; Wijnen, Juul; Gómez, E.; J. L. Ligtenberg, Marjolijn; Kriege, Mieke; Margriet Collée, J.; G.E.M. Ausems, Margreet; C. Oosterwijk, Jan; Peock, Susan; Frost, Debra; D. Ellis, Steve; Platte, Radka; Fineberg, Elena; Gareth Evans, D.; Lalloo, Fiona; Jacobs, Chris; A. Eeles, Rosalind; Adlard, Julian; Davidson, Rosemarie; Cole, Trevor; Cook, Jackie; Paterson, Joan; Douglas, Fiona; Brewer, Carole; Hodgson, Shirley; J. Morrison, Patrick; Walker, Lisa; T. Rogers, Mark; Donaldson, Alan; Dorkins, Huw; K. Godwin, Andrew; Bove, Betsy; Stoppa‐Lyonnet, Dominique; Houdayer, Claude; Buecher, Bruno; De Pauw, Antoine; Mazoyer, Sylvie; Calender, Alain; Léoné, Mélanie; Bressac–de Paillerets, Brigitte; Caron, Olivier; Sobol, Hagay; Frénay, Marc; Prieur, Fabienne; Fert Ferrer, Sandra; Mortemousque, Isabelle; S. Buys, Saundra; B. Daly, Mary; Miron, Alexander; Beth Terry, Mary; L. Hopper, John; M. John, Esther; C. Southey, Melissa; E. Goldgar, David; F. Singer, Christian; Fink-Retter, A.; Tea, Muy‐Kheng; Geschwantler Kaulich, Daphne; van Overeem Hansen, Thomas; C. Nielsen, Finn; B. Barkardóttir, Rósa; M. Gaudet, Mia; Kirchhoff, Tomas; Vijai, Joseph; Dutra-Clarke, Ana; Offit, Kenneth; Piedmonte, Marion; Kirk, Judy; E. Cohn, David; Hurteau, Jean; Byron, John; V. Fiorica, James; E. Toland, Amanda; Montagna, Marco; Oliani, Cristina; Imyanitov, Evgeny; Isaacs, Claudine; Tihomirova, Laima; Blanco, Ignacio; Lázaro, Conxi; Teulé, Àlex; Del Valle, Jesús; A. Gayther, Simon; Odunsi, Kunle; Gross, Jenny; Karlan, Beth; Oláh, Edith; Teo, Soo‐Hwang; A. Ganz, Patricia; Beattie, Mary; M. Dorfling, Cecelia; J. van Rensburg, Elizabeth; Dı́ez, Orland; Kwong, Ava; K. Schmutzler, Rita; Wappenschmidt, Barbara; Engel, Christoph; Meindl, Alfons; Ditsch, Nina; Arnold, Norbert; Heidemann, Simone; Niederacher, Dieter; Preisler-Adams, Sabine; Gadzicki, Dorothea; Varon-Mateeva, Raymonda; Deißler, Helmut; Gehrig, Andrea; Sutter, Christian; Kast, Karin; Fiebig, Britta; Schäfer, Dieter; Caldes, Trinidad; de la Hoya, Miguel; Nevanlinna, Heli; Muranen, Taru; Lespérance, Bernard; B. Spurdle, Amanda; L. Neuhausen, Susan; Chun Ding, Yuan; Wang, Xianshu; Fredericksen, Zachary; Shane Pankratz, V.; M. Lindor, Noralane; Peterlongo, Paolo; Manoukian, Siranoush; Peissel, Bernard; Zaffaroni, Daniela; Bonanni, Bernardo; Bernard, Loris; Dolcetti, Riccardo; Papi, Laura; Ottini, Laura; Radice, Paolo; H. Greene, Mark; T. Loud, Jennifer; L. Andrulis, Irene; Özçelik, Hilmi; Marie Mulligan, Anna; Glendon, Gord; Thomassen, Mads; Gerdes, Anne‐Marie; Birk Jensen, Uffe; Skytte, Anne‐Bine; A. Kruse, Torben; Chenevix‐Trench, Georgia; J. Couch, Fergus; Simard, Jacques; F. Easton, Douglas; SWE-BRCA, CIMBA,; , HEBON; , EMBRACE; Collaborators Study, GEMO; Investigators, kConFab

doi:10.1186/bcr3121

Public

Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2mutation carriers

Published in Breast Cancer Research • Feb 20, 2012

Authors:

Antonis C. Antoniou

Karoline Kuchenbaecker

Penny Soucy

Abstract

INTRODUCTION: Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility loci: rs1011970 (9p21, CDKN2A/B), ...

Subject

Breast cancer

Surgical oncology

Medicine

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