Roles for Insulin Receptor, PI3-Kinase, and <i>Akt</i> in Insulin-Signaling Pathways Related to Production of Nitric Oxide in Human Vascular Endothelial Cells

Zeng, Guangyuan; H. Nystrom, Frederick; V. Ravichandran, Lingamanaidu; Cong, Li-Na; Kirby, Martha; Mostowski, Howard; J. Quon, Michael

doi:10.1161/01.cir.101.13.1539

Public

Roles for Insulin Receptor, PI3-Kinase, and Akt in Insulin-Signaling Pathways Related to Production of Nitric Oxide in Human Vascular Endothelial Cells

Published in Circulation • Apr 4, 2000

Authors:

Guangyuan Zeng

Frederick H. Nystrom

Lingamanaidu V. Ravichandran

Abstract

BACKGROUND: Previously, we demonstrated that insulin stimulates production of nitric oxide (NO) in endothelial cells. However, specific insulin-signaling pathways mediating production of NO have not been elucidated. METHODS AND RESULTS: We developed methods for transfection of human umbilical vein e...

Subject

Insulin receptor

Protein kinase B

Insulin

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