Lowe Syndrome Protein OCRL1 Interacts with Clathrin and Regulates Protein Trafficking between Endosomes and the <i>Trans</i>-Golgi Network

Choudhury, Rawshan; Diao, Aipo; Zhang, Fang; Eisenberg, Evan; Saint‐Pol, Agnès; Williams, Catrin; Konstantakopoulos, Athanasios; M. Lucocq, John; Johannes, Ludger; Rabouille, Cathérine; E. Greene, Lois; Lowe, Martin

doi:10.1091/mbc.e05-02-0120

Public

Lowe Syndrome Protein OCRL1 Interacts with Clathrin and Regulates Protein Trafficking between Endosomes and the Trans-Golgi Network

Published in Molecular Biology of the Cell • May 26, 2005

Authors:

Rawshan Choudhury

Aipo Diao

Fang Zhang

Abstract

Oculocerebrorenal syndrome of Lowe is caused by mutation of OCRL1, a phosphatidylinositol 4,5-bisphosphate 5-phosphatase localized at the Golgi apparatus. The cellular role of OCRL1 is unknown, and consequently the mechanism by which loss of OCRL1 function leads to disease is ill defined. Here, we s...

Subject

Endosome

Clathrin

Cell biology

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