Inflammatory disease in HLA‐B27 transgenic rats

D. Taugor, Joel; D. Maika, Shanna; Satumtira, Nimman; L. Dorris, Martha; L. McLEAN, I.; Yanagisawa, Hiromi; Sayad, Alain; J. Stagg, Andrew; M. Fox, Graham; Le O'Brein, Anne; Rehman, Muhammad; Zhou, Ming; L. Weiner, Allison; Splawski, Judy; A. Richardson, James; E. Hammer, Robert

doi:10.1111/j.1600-065x.1999.tb01317.x

Public

Inflammatory disease in HLA‐B27 transgenic rats

Published in Immunological Reviews • Jun 1, 1999

Authors:

Joel D. Taugor

Shanna D. Maika

Nimman Satumtira

Abstract

UNLABELLED: A spontaneous inflammatory disease in rats transgenic for HLA-B27 resembles the B27-associated human spondyloarthropathies. Colitis and arthritis, the two most important features, require T cells, gut bacteria, and high expression of B27 in bone marrow-derived cells. Control rats with HL...

Subject

HLA-B27

Immunology

Arthritis

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