The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54

Kotani, Masato; Detheux, Michel; L. Vandenbogaerde, Ann; Communi, David; Vanderwinden, Jean‐Marie; Le Poul, Emmanuel; Brézillon, Stéphane; Tyldesley, Richard; Suarez-Huerta, Nathalie; Vandeput, Fabrice; Blanpain, Cédric; N. Schiffmann, Serge; Vassart, Gilbert; Parmentier, Marc

doi:10.1074/jbc.m104847200

Public

The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54

Published in Journal of Biological Chemistry • Sep 1, 2001

Authors:

Masato Kotani

Michel Detheux

Ann L. Vandenbogaerde

Abstract

Natural peptides displaying agonist activity on the orphan G protein-coupled receptor GPR54 were isolated from human placenta. These 54-, 14,- and 13-amino acid peptides, with a common RF-amide C terminus, derive from the product of KiSS-1, a metastasis suppressor gene for melanoma cells, and were t...

Subject

KISS (TNC)

Kisspeptin

Gene

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