Facile Discrimination of Aldose Enantiomers by Reversed-Phase HPLC

Tanaka, Takashi; Nakashima, Tatsuya; Ueda, Toshihisa; Tomii, Kenji; Kouno, Isao

doi:10.1248/cpb.55.899

Public

Facile Discrimination of Aldose Enantiomers by Reversed-Phase HPLC

Published in Chemical and Pharmaceutical Bulletin • Jan 1, 2007

Authors:

Takashi Tanaka

Tatsuya Nakashima

Toshihisa Ueda

Abstract

One-pot reactions of aldoses with L-cysteine methyl ester and o-tolyl isothiocyanate yielded methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbamoyl)-thiazolidine-4(R)-carboxylates. Direct HPLC analysis of the reaction mixture and UV detection at 250 nm discriminated D- and L-enantiomers of aldoses. The...

Subject

Chemistry

Enantiomer

Aldose

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