Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma.

Rosenwald, Andreas; Wright, George; Leroy, Karen; Yu, Xin; Gaulard, Philippe; D Gascoyne, Randy; C Chan, Wing; Zhao, Tong; Haioun, Corinne; C Greiner, Timothy; D Weisenburger, Dennis; C Lynch, James; Vose, Julie; O Armitage, James; B Smeland, Erlend; Kvaloy, Stein; Holte, Harald; Delabie, Jan; Campo, Elias; Montserrat, Emili; Lopez-Guillermo, Armando; Ott, German; Konrad Muller-Hermelink, H; M Connors, Joseph; Braziel, Rita; M Grogan, Thomas; I Fisher, Richard; P Miller, Thomas; LeBlanc, Michael; Chiorazzi, Michael; Zhao, Hong; Yang, Liming; Powell, John; H Wilson, Wyndham; S Jaffe, Elaine; Simon, Richard; D Klausner, Richard; M Staudt, Louis

doi:10.1084/jem.20031074

Public

Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma.

Shared by NobleBlocks on Sep 15, 2003 • 12:00 AM UTC

Authors:

Andreas Rosenwald

George Wright

Karen Leroy

Abstract

Using current diagnostic criteria, primary mediastinal B cell lymphoma (PMBL) cannot be distinguished from other types of diffuse large B cell lymphoma (DLBCL) reliably. We used gene expression profiling to develop a more precise molecular diagnosis of PMBL. PMBL patients were considerably younger t...

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